Your Questions Answered

Alerten Q100

Alerten Q100 (4)

How long can I take Q10?

Q10 is generally considered a very safe substance. Long-term studies of more than 5 years as well as studies with high daily doses have shown that it is safe to take supplements of Q10 for a long period. In addition, supplementation of Q10 does not reduce the body's own production of the substance. After cessation of supplementation, the body's Q10-level returns to the same level as before. This is proof that Q10 supplementation does not affect the body's ability to synthesize it. Everything indicates that you can safely continue to take Q10 for life.



Are there adverse effects from Q10?

In studies in which Q10 has been tested, daily doses up to 1500 mg have not caused adverse effects of a serious nature. There have only been a very few cases of adverse effects of a mild nature. Symptoms like headache, dizziness, nausea, constipation, diarrhea and indigestion can occur in rare instances. It cannot be excluded, however, that some of these symptoms may originate from the capsule material or added vegetable oil, and not from the Q10 itself.



Does cholesterol lowering drugs reduce the body's level of Q10?

Yes, there is now a great deal of evidence from scientific studies on the consequences of this effect. The type of medication in question is commonly referred to as "statins". Statins are a class of cholesterol-lowering drugs that act by inhibiting the enzyme HMG-CoA reductase, which reduces the body's production of the substance mevalonate. From mevalonate, several substances are formed in the liver, including cholesterol and Q10. You cannot lower the body's cholesterol production in this way without also lowering its production of Q10.

There are different types of statins working in different ways, and they are not equally strong. The most common complaint about the adverse effects of statins is muscle pain. The pain occurs when the muscles have to work with too little energy. However, not everybody experiences adverse effects from statins. The effect differs from individual to individual depending on how much Q10 is required to normalize the body's Q10 level during statin treatment. You must monitor your own body’s needs.



How much Q10 do we need?

Our needs for Q10 are individual. Healthy young people usually have no need for supplementation of Q10. Healthy adults should take maybe 30 - 60 mg daily. Elderly people could take maybe 100 mg daily. People in therapeutic treatment have been given up to 300 mg daily - occasionally even more than that.



How long does it take for Q10 to work?

From the moment you swallow a Q10 softgel capsule, which is best absorbed with a meal that contains some fat, it will take 6-8 hours before the Q10 is emptied into the blood from the lymphatic vessels. There is also a threshold value for the blood level of Q10 that has to be attained before the tissue can absorb the Q10 sufficiently. This threshold value of serum Q10 has not been established with certainty, but researchers believe that it is approx. 2 - 2,5 ug/ml.

In practical terms, this means that it is advisable to start with a slightly higher daily dose and then reduce the dose after some time if necessary. Take Q10 for at least a month, but do not expect maximum absorption in the tissue until after at least six months of use.



What is the source of Alerten's Q10?

Alerten's Q10 is extracted from the content produced in specialized yeast cells, but the Q10 itself is completely free of yeast components. The reason for the use of yeast as a source of Q10 is that we can extract Q10, which is completely identical to the form that the body produces itself. Please be aware that there is also synthetic Q10 on the market.



How can I avoid eating the gelatin in the Q10 capsules?

You can cut a small hole in the softgel capsule with a pair of scissors and squeeze the contents of the capsule out in a spoon or directly into your mouth.



Is the gelatin in your Q10 capsules Halal certified?

Yes. All the bovine gelatin of Mega products including Alerten is Halal certified. The certification comes from the Halal Department of the Islamic and Cultural Centre of Thailand which recognized by JAKIM.


Given the strength of the science that has been emerging for the use of supplemental CoQ10, it is important to ensure that optimal CoQ10 levels are achieved in the blood following supplementation. Alerten Q100 is unique among coenzyme Q10 products as it utilizes the patented VESIsorb® technology from Switzerland to deliver coenzyme Q10 without the need for concomitant fat consumption.

When mixed with an aqueous system, this patented technology results in the formation of a nano-colloid containing solubilized CoQ10. This association colloid delivery system contains a highly uniform distribution of droplets that are less than 100 nm in diameter. The size and structure of these droplets allow for enhanced solubility and absorption of coenzyme Q10 (figure 1).


Figure 1

This image represents the structure of a nano-colloid droplet which consists of a monolayer with the coenzyme Q10 contained within the core. The formation of the colloidal system upon contact with an aqueous environment (such as the lumen of the intestine) enables the solubilized CoQ10 to more easily diffuse across the unstirred water layer that is present between the enterocyte and the lumen of the intestine (figure 2).


Figure 2

One can demonstrate the enhanced solubility of the CoQ10 contained in Alerten Q100 by placing a capsule in warm water. Once the capsule opens, the contents can be easily mixed with the water, resulting in the formation of the association colloid. There is no separation of oil and water phases as is typical with more traditional CoQ10 delivery systems. In a clinical study in humans, supplementation with CoQ10 utilizing the patented VESIsorb® technology resulted in greater absorption compared with other CoQ10 products (figure 3).


Figure 3




CoQ10 is naturally orange and found in most cells in the body. CoQ10 helps support cellular energy production in the mitochondria – the powerhouses of most cells. The highest concentrations of cellular mitochondria are found in the hardest working cells in the body, such as the heart, making CoQ10 an important nutrient to help support heart function.

Moderate amounts of CoQ10 are found in foods, but the primary source of CoQ10 in the body is produced by the body itself. CoQ10 levels decrease with age and some cholesterol-lowering statin drugs can reduce CoQ10 production, which is why supplementing may be helpful to replenish CoQ10 levels in the body.

How Statins and CoQ10 are related?

Although muscle pain and discomfort is common when taking statins, some people experience more serious problems, including something known as rhabdomyolysis. This process occurs when muscle cells break down. As muscles collapse, a muscle protein is released into the bloodstream. This in turn can cause severe kidney problems.

In a study published in the American Journal of Cardiology, researchers indicate that coenzyme Q10 seems to decrease muscle breakdown and reduce pain and discomfort on people taking statins.

Coenzyme Q10 deficiency may occur due to disease, low dietary intake, or high CoQ10 use by the body. Symptoms of deficiency include heart failure, high blood pressure, and chest pain. Depending on the cause of deficiency, supplementing with CoQ10 or increasing dietary intake may be effective.


Without the assistance of technology Q10 is poorly absorbed

One of the biggest challenges associated with Q10 as a supplement is that the substance generally is not readily absorbed by the body. Q10 in other words, has a low bioavailability. The Q10 molecule is a relatively large molecule and this is the main reason for its poor absorption in the body and as a result of its molecular structure, it is fat soluble.


Most documentation on ubiquinone

Q10 is found in two forms. An oxidized form called ubiquinone as well as a reduced form called ubiquinol. Ubiquinol is also marketed as active Q10 although ubiquinol isn't more active than ubiquinone. The form of Q10 we produce in our cells, is the oxidized ubiquinone. Also Q10 from our food is predominantly the oxidized form. When we absorb the oxidized ubiquinone from the intestine it is automatically converted to reduced ubiquinol. In the blood and lymphatic system 90-95% of Q10 is in the form of ubiquinol. In the cells' energy-producing mitochondria Q10 alternate continuously between these two forms, a feature that is crucial for Q10s effects in the body.

Therefore, it is of minor importance what form of Q10 you consume, your body will still convert the oxidized ubiquinone to reduced ubiquinol. To date, almost all documentation on efficacy and safety are done with the oxidized form, ubiquinone.

Ubiquinone = oxidized Q10
Ubiquinol = reduced Q10